منابع مشابه
p53 further extends its reach
p53 is a central sensor of severe cellular insults, including genotoxic, oxidative and oncogenic stress. Depending on the context, p53 cell-autonomously orchestrates responses of temporary cell cycle arrest coupled to DNA repair or permanent senescence, or it induces apoptotic, autophagic and necrotic forms of cell death. However, little is known about the noncell autonomous effects of p53. Rec...
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TOR (Target of Rapamycin) pathway accelerates cellular and organismal aging. Similar to rapamycin, p53 can inhibit the mTOR pathway in some mammalian cells. Mice lacking one copy of p53 (p53+/- mice) have an increased cancer incidence and a shorter lifespan. We hypothesize that rapamycin can delay cancer in heterozygous p53+/- mice. Here we show that rapamycin (given in a drinking water) extend...
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Listeria monocytogenes is a facultative pathogenic bacterium that lives in the environment as a saprophyte but can turn into a harmful pathogen affecting humans as well as animals upon ingestion. These bacteria have the remarkable capacity to actively invade eukaryotic host cells, to multiply within them, and to spread to neighbouring cells (Freitag et al., 2009). The transition from an environ...
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chapter i provides an overview of structural linguistics and touches upon the saussurean dichotomies with the final goal of exploring their relevance to the stylistic studies of literature. to provide evidence for the singificance of the study, chapter ii deals with the controversial issue of linguistics and literature, and presents opposing views which, at the same time, have been central to t...
15 صفحه اولNew perspective on targeting the tumor suppressor p53 pathway in the tumor microenvironment to enhance the efficacy of immunotherapy
About 50% of human cancers harbor somatic mutations of the tumor suppressor p53 (p53 or Trp53) gene. Many of those mutations result in the inactivation of the p53 pathway and are often associated with the stabilization and accumulation of mutant p53 proteins. Therefore, increased p53 expression in tumors is frequently used as a surrogate marker for p53 mutation and inactivation. Moreover, this ...
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ژورنال
عنوان ژورنال: Nature Cell Biology
سال: 2013
ISSN: 1465-7392,1476-4679
DOI: 10.1038/ncb2787